HIV infection aggravates the progression of liver damages in HCV-coinfected patients,and the underlying pathogenesis is multifactorial.Although high oxidative stress was frequently delineated in HIV or HCV monoinfection,the status of oxidative stress in HIV/HCV coinfection and its contribution to HCV liver damages are lack of understanding.In our study,363 HBsAg negative and anti-HCV positive former blood donors were recruited from a village of central China in July 2005 and 282 subjects were successfully followed up in July 2009.