Substrate stiffness regulates annulus fibrosus-derived stem cells in cellular, gene expression of ex

来源 :第七届国际骨质疏松及骨矿盐疾病学术会议 | 被引量 : 0次 | 上传用户：JK0803_lijixiang

【摘要】

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【作者】

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Chen Liu Jun Li Huilin yang Bin Li

【机构】

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Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, Ch

【出处】

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第七届国际骨质疏松及骨矿盐疾病学术会议

【发表日期】

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2014年3期

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Background: Annulus fibrosus (AF) regeneration is critical to intervertebral disc repair, yet remains challenging due to the remarkable heterogeneity of AF tissue.Since the stiffness of substrate determines stem cell lineage commitment (Cell 2006, 126:677-89), this study aimed to explore whether the differentiation of AF-derived stem cells (AFSCs) (PLoS One 2014, accepted), a newly identified cell source for AF tissue engineering, could be regulated by substrate stiffness.

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