谷氨酰胺双肽对围手术期患者血浆内毒素水平、内毒素灭活能力、临床预后和卫生经济学指标的影响(40例随机、双盲、对照和单中心的临床研究)

来源 :中国协和医科大学 中国医学科学院 北京协和医学院 清华大学医学部 | 被引量 : 0次 | 上传用户:jerklie198091
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目前,关于择期大手术患者发生内毒素血症的具体时间有不同的报导.另外,血浆被认为是内毒素强有力的灭活剂,即血浆具有很强的灭活内毒素的能力,国内这方面尚无报告.手术后应用谷氨酰胺有保护肠道粘膜屏障和增强机体免疫的功能,有报告认为创伤和应激情况下短期内出现血浆中谷氨酰胺水平的下降,提供了围手术期应用谷氨酰胺的理论基础.该文研究了(1)建立测定血浆内毒素水平和血浆灭活内毒素能力的可靠方法,观察围手术期血浆内毒素水平和血浆灭活内毒素能力的变化.(2)研究围手术期应用谷氨酰胺双肽对血浆内毒素水平、血浆灭活内毒素能力及预后的影响.
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