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Objective:To analyze 181 cases of patients with Type 2 Diabetes, cardiovascular risk factors, the basic information of clinical aspirin resistance, platelet and morphological differences, aspirin and its metabolites, to find out the risk factors, the phenomenon of clinical aspirin resistance in patients with Type 2 Diabetes Mellitus in order. The relationship and its metabolites, TCM syndrome type distribution. The relationship between syndrome type of traditional Chinese medicine research and the main risk factors, early intervention and treatment.Methods:Analysis of the basic information, for a total of 181 patients with type 2 diabetes mellitus patients with plateletmorphology, pharmacodynamics index and main metabolite salicylic acid, the use of SPSS 17.0 for data processing.Results:In patients with type 2 diabetes are at high risk of clinical aspirin, a level of glycated hemoglobin, uric acidand high density lipoprotein cholesterol level and the ratio of TXB2/6-K and salicylic acid concentration in bloodmay be related factors (P<0.05). However, different gender, different age groups and different levels of blood lipids, blood glucose control level, different levels of uric acid in patients with type 2 diabetes, aspirin efficacywithout significant difference P>0.05. The blood concentration of salicylic acid plays an important role in patients with type 2 diabetes clinical aspirin resistance, the T2DM-AR mechanism is the accumulation of salicylic acid.Patients with salicylic acid concentrations of T2DM-AR compared with T2DM-NAR significantly increased, with statistical significance. The longitudinal comparison of salicylic acid concentration is influenced by theconcentration of serum uric acid. In five kinds of TCM syndrome of type 2 diabetes mellitus common type, blood stasis type 2 diabetes clinical aspirin resistance in high-risk syndrome type and efficacy of aspirin compared with other TCM syndrome type, the results were statistically significant.Conclusion:1.Patients with Type 2 diabetes clinical aspirin resistance and the levels of glycosylated hemoglobin,uric acid, the level of high density lipoprotein, TXB2/6-K ratio, blood concentration of salicylic acid (P<0.05) related.2.Salicylic acid accumulation in patients with type 2 diabetes clinical aspirin resistance may be one of the mechanisms of.3.Clinical aspirin resistance in patients with blood stasis was the high incidence of poor efficacy, and aspirin(P<0.05).