IntroductionOne method used to accelerate orthodontic tooth movement is the Periodontally Accelerated Osteogenic Orthodontics (PAOO) technique. The purposes of this study were to(1) identify the effect of the PAOO technique on orthodontic tooth movement compared with the standard tooth-movement technique, and(2) explore the histologic basis of the difference between the2techniques.Methods20female rabbits were used for this study. All Experimental rabbits underwent surgical PAOO treatment using a mini screw applied with continuous force of125mg. All control groups were given non-surgical mini screw intervention with a continuous force of125mg. The rabbits were killed in the first, second, third, and seventh weeks after orthodontic force application.ResultsThe average total tooth movement between the control and PAOO group revealed; during the first and second week no significant difference was found between them (P>.05). The amount of tooth movement was significantly increased in the PAOO group during the third and seventh week.(P<0.05)Histologic findings showed more active and extensive bone remodeling on PAOO group.ConclusionsOrthodontic tooth movement increased for at least2weeks after the PAOO. This might be brought about by rapid alveolar bone reaction in the bone marrow cavities, which leads to less hyalinization of the periodontal ligament on the alveolar wall; and promote the rate of bone remodeling.