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The topic of my thesis is prokinetic drugs for functional dyspepsia and it involves Methodology,objective,design,discussion,review,conclusion and results.I have studied rome IV for my thesis and did my research by following rome IV model for FD during my research I have given different medication to treat FD such as erythromycin,metoclopramide,domperidone,cisapride,itopride,tandosprione citrate,alosetron,tegaserod,mosapride and acotiamide.This treatment was about for seven days by giving such a treatment I have got a different outcome and symptoms of improvement in patient I have further implemented different attachments such as central search strategy OVID,midline search strategy and bass search strategy in CINAHL search strategy the methodology involve the measure of treatment effects analysis issues dealing with missing data,and as well as contain the assessment of heterogeneity for the data synthesis globally symptoms for dyspepsia will be classified the results for different drugs for dyspepsia are given below,Prokinetic with another prokinetics primary and secondary result should be involved during results I focused on analysis and investigation I have mentioned different prokinetics agents such is CISAPRIDE,TEGASEROD,PRUCALOPRIDE,VELUSETRAG,NARONPRIDE,RENSP RIDE,CLEBROPRIDE and MOSAPRIDE,there are some drugs which are no longer available in market because of their side effects such as cisapride pride,this drug has very dangerous effect on patient health such as for those patient who are having cardio problem and this cause death.and another drug is Tegaserod the 5-HT4 the brand name of this drug is Zelnorm-Zelmac and this use for constipation this was approved in 2007 but this drug isn’t available in market anymore because this have same side effects on patient as a cisapride had.there are other drugs such as PRUCALOPRIDE,VELUSETRAG,NARONAPRIDE are still available in market and they haven’t any side effects on human body.but such as renzapride,clebopride and mosapride are no longer treatable because these drugs don’t show any safety.we do have more prokinetic agents such as Lubiprostone,Linaclotide,plecanatide for acid modulators we use bile acid modulator for diarrhea and constipation disorder.The CDC are primary bile acid but does have strong effect on physiology treatment this is why we use this for the physiologic laxative.The elobixibat have some potential benefits from currently approved drugs such as prucaloride,lubiprostone,linaclotide we gave this to 30 patients and the result wasn’t bad that’s why these drugs still perform its good and positive role without showing any side effects