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目的:探讨宫颈原发性恶性黑色素瘤(primary malignant melanoma of the u-terine cervix)的临床病理学特征、诊断及鉴别诊断。方法:检测6例原发性宫颈恶性黑色素瘤的组织病理学和免疫组化结果并复习文献。结果:患者28岁～83岁,平均53岁。主要临床表现为阴道不规则流血、阴道分泌物增多及发现宫颈肿物。肿瘤大体检查呈息肉样、溃疡状或平坦形。镜下肿瘤组织结构复杂、细胞形态多样,主要由胞质透亮的上皮样细胞和梭形细胞组成,核呈多形性,嗜酸性核仁显著,黑色素颗粒或有或无。免疫组化显示HMB-45和Melan-A或S-100表达呈阳性。结论:宫颈原发性恶性黑色素瘤罕见,借助于临床病理特点及免疫组化检查可与其它类似病变鉴别。
Objective: To investigate the clinicopathological features, diagnosis and differential diagnosis of primary malignant melanoma of the u-terine cervix. Methods: Six cases of primary cervical malignant melanoma histopathological and immunohistochemical results and review the literature. Results: The patients were 28 years old to 83 years old with an average of 53 years old. The main clinical manifestations of vaginal irregular bloodshed, increased vaginal discharge and cervical tumor found. Tumor gross examination showed polypoid, ulcer-like or flat-shaped. Microscopic tumor tissue complex structure, cell morphology, mainly by the cytoplasm translucent epithelial cells and spindle cells, nuclear was pleomorphic, eosinophilic significant nucleoli, melanin granules with or without. Immunohistochemistry showed positive expression of HMB-45 and Melan-A or S-100. Conclusion: The rare cervical primary malignant melanoma, with the help of clinicopathological features and immunohistochemistry can be identified with other similar lesions.