已证实边缘性高血压经治疗后死亡率和严重并发症的发生率明显降低。边缘性高血压和属血压正常高界范围者虽然远较严重高血压者不易发生卒中,但因其人数众多,群体实际所得发生卒中危险性(即暴露人数×危险率)实远较后者大。因此,对上述对象开展有关原发性高血压(essential hypertension,EHT)和卒中的一级预防研究便显得特别重要。为了对疾病的因果关系和预防提供证据,必需将临床、流行病学和实验研究三者有机结合起来。60年代后众多自发性高血压动物模 The morbidity and mortality of marginal hypertension have been significantly reduced after treatment. Although marginal hypertension and those with high blood pressure are not prone to stroke much more often than those with severe hypertension, the actual risk of stroke (ie, the number of exposures × risk) is far greater than that of the latter because of the large number . Therefore, it is of particular importance to conduct primary prevention studies on essential hypertension (EHT) and stroke in these subjects. In order to provide evidence for the causal relationship between disease and prevention, it is necessary to combine clinical, epidemiological and experimental studies. Many spontaneous hypertensive animal models after the 1960s