目的　探讨儿童组织细胞坏死性淋巴结炎的临床表现及病理特征。方法　本组 2 4例患儿 ,均经淋巴结活检病理确诊。给予强的松口服治疗 12周。结果　 2 4例淋巴结病理组织学均可见淋巴结部分结构消失 ,皮质区内凝固性坏死 ,病变区及周围无中性粒细胞浸润。经治疗后 2 4例均临床治愈 ,随访 1～ 3年 ,预后良好。结论　对临床上长期高热、颈部淋巴结肿大伴粒细胞减少的患儿 ,应做淋巴结病理活检或穿刺行细胞学检查 ,做出正确诊断。明确诊断后给予糖皮质激素治疗 ,预后良好 Objective To investigate the clinical manifestations and pathological features of children’s tissue necrosis lymphadenitis. Methods 24 cases of children in this group were confirmed by lymph node biopsy. Give prednisone oral treatment for 12 weeks. Results The histopathology of lymph nodes showed disappearance of part of the structure of lymph nodes, coagulation and necrosis in cortical area, neutrophil infiltration in and around the lesion area. After treatment 24 cases were clinically cured, followed up for 1 to 3 years, the prognosis is good. Conclusion Clinic patients with long-term high fever, cervical lymph node enlargement with neutropenia in children, should do lymph node biopsy or biopsy cytology to make the correct diagnosis. Given a clear diagnosis of glucocorticoid therapy, the prognosis is good