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目的探讨羚蝎胶囊治疗缺血性中风的作用机制。方法将30只SD大鼠随机分为假手术组、模型组、羚蝎胶囊组。采用穿线法阻断大脑中动脉(MCAO)复制大鼠脑缺血再灌注模型,假手术组不予插线。手术前7天及术后24h内,羚蝎胶囊组灌喂羚蝎胶囊混悬液,其余两组分别灌喂0.9%的NaCl溶液。术后24h取材,检测脑组织超氧化物歧化酶(SOD)和丙二醛(MDA)的含量。结果与模型组相比,羚蝎胶囊组的SOD水平明显升高,MDA水平显著下降,两组差异有统计学意义(P<0.05)。结论羚蝎胶囊可保护脑组织缺血再灌注后引发的自由基损伤,其作用可能与减轻缺血再灌注后脑组织的损害有关。
Objective To explore the mechanism of Antelope Scorpio Capsule in treating ischemic stroke. Methods Thirty Sprague-Dawley rats were randomly divided into sham operation group, model group and antelope scorpion capsule group. The cerebral ischemia-reperfusion model of middle cerebral artery (MCAO) -repeated rats was blocked by threading method, while the sham operation group was not inserted. 7 days before and 24 hours after surgery, the Antelope scorpio capsule group was infused with antelope scorpio capsule suspension, and the remaining two groups were fed 0.9% NaCl solution. After 24h, the contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in brain tissue were determined. Results Compared with the model group, the SOD in the antelope scorpion capsule group was significantly increased, while the MDA level was significantly decreased. The difference between the two groups was statistically significant (P <0.05). Conclusion Antelope scorpion capsule can protect brain tissue from ischemia-reperfusion induced free radical damage, its role may be related to reducing the damage of brain tissue after ischemia-reperfusion.