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目的探讨糖皮质激素(GC)及其受体(GR)与分娩启动的关系。方法40例足月剖宫产孕妇均分为临产后剖宫产(A)组及选择性剖宫产(B)组。孕妇均无妊娠合并症及并发症,孕期未使用GC。检测血清及羊水中GC水平。采用免疫组化和RT-PCR技术检测胎盘、胎膜组织GR-α和GR-β的表达。结果A组血清GC水平明显高于B组(P<0.05)。两组胎盘组织几乎无GR表达;A组胎膜组织中GR-β表达明显低于B组,GR-α/GR-β比例高于B组(P<0.05)。结论临产后血清GC增加,胎膜上GR-β的表达降低,GR-α/GR-β增高,可能与分娩启动相关。
Objective To investigate the relationship between glucocorticoid (GC) and its receptor (GR) and labor initiation. Methods Forty pregnant women with term cesarean section were divided into three groups: cesarean section (A) and selective cesarean section (B). Pregnant women have no pregnancy complications and complications, pregnancy did not use GC. Detection of serum and amniotic fluid GC levels. Immunohistochemistry and RT-PCR were used to detect the expression of GR-α and GR-β in placenta and fetal membranes. Results The level of serum GC in group A was significantly higher than that in group B (P <0.05). There was almost no GR expression in placenta of both groups. The expression of GR-β in group A was significantly lower than that in group B, and the ratio of GR-α / GR-β was higher than that in group B (P <0.05). Conclusions Serum GC increased after labor, the expression of GR-β in fetal membranes decreased and GR-α / GR-β increased, which may be related to the initiation of labor.