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白细胞介素 - 12 (IL - 12 )是由抗原提呈细胞分泌表达的一种细胞因子 ,由 P35和 P40两条多肽链结合而成的异源二聚体。 IL - 12具有抗乙型肝炎病毒 (HBV)的作用 ,其作用机制的研究主要集中在 Th1/ Th2细胞平衡和诱生γ干扰素 (IFN- γ)两方面。 IL- 12有望应用于慢性肝炎的临床治疗。
Interleukin - 12 (IL - 12) is a cytokine secreted by antigen - presenting cells and is a heterodimer composed of two P35 and P40 polypeptide chains. IL - 12 has the anti - hepatitis B virus (HBV) effect. Its mechanism of action is mainly focused on the balance of Th1 / Th2 cells and the induction of interferon - γ (IFN - γ). IL-12 is expected to be used in the clinical treatment of chronic hepatitis.