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目的:观察人参二醇皂苷(Panaxdiols Saponin,PDS)对急性血瘀模型大鼠血液流变性及PGF1a和TXB2的影响。方法:Wistar大鼠60只,随机分为6组:对照组;模型组;阳性对照组;PDS5,10,20mg·kg-13个剂量组。采用sc肾上腺素加冰水冷浴法制备大鼠急性血瘀模型,舌下iv给药,观察PDS对急性血瘀模型大鼠血液流变性及PGF1a和TXB2的影响。结果:PDS能降低急性血瘀模型大鼠全血黏度,增加心、肺组织中PGF1a含量,减少TXB2含量。结论:PDS对急性血瘀模型大鼠血液流变性异常有明显改善作用,能纠正PGF1a与TXB2之间的平衡失调。
Objective: To observe the effect of panaxdiols saponin (PDS) on hemorheology and PGF1a and TXB2 in acute blood stasis model rats. Methods: 60 Wistar rats were randomly divided into 6 groups: control group, model group, positive control group, PDS5, 10, 20 mg·kg-13 dose groups. Rats with acute blood stasis model were prepared by cryoadrenaline and ice-cold water bath and sublingual iv administration. The effects of PDS on hemorheology and PGF1a and TXB2 in acute blood stasis model rats were observed. Results: PDS can reduce the blood viscosity of acute blood stasis model rats, increase the content of PGF1a in heart and lung tissue, and reduce TXB2 content. Conclusion: PDS can significantly improve the hemorheological abnormality in rats with acute blood stasis, and can correct the imbalance between PGF1a and TXB2.