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目的研究Ⅳ型胶原的血清检测对肝纤维化的诊断价值。方法采用酶标方法对各种肝病进行Ⅳ型胶原的检测。结果血清Ⅳ型胶原水平以慢性肝炎（ＣＨ）、肝硬化（ＬＣ）及肝细胞癌（ＨＣＣ）为最高，分别为（２５０±７８）、（２７８±９５）及（２６８±８９）ｎｇ／ｍｌ。急性肝炎（ＡＨ）及脂肪肝（ＦＬ）的Ⅳ型胶原无明显变化。肝组织纤维化程度与Ⅳ型胶原的血清水平也有一定关系，Ｓ２期有所提高，以Ｓ３～Ｓ４期为最高。Ⅳ型胶原水平与前白蛋白（ＰＡ）水平呈负相关（ｒ＝０．５３２１，Ｐ＜０．０１），但与ＡＬＴ及Ｓｂ无关。结论Ⅳ型胶原血清水平能较好地反映肝纤维化的程度，为早期诊断肝纤维化提供了一个敏感的指标。
Objective To study the diagnostic value of serum of type Ⅳ collagen on liver fibrosis. Methods Enzyme - labeled method was used to detect type Ⅳ collagen in various liver diseases. Results The serum levels of type Ⅳ collagen were highest in patients with chronic hepatitis (CH), liver cirrhosis (LC) and hepatocellular carcinoma (HCC), and were (250 ± 78), (278 ± 95) and (268 ± 89) ng / ml . Type A collagen in acute hepatitis (AH) and fatty liver (FL) showed no significant change. Liver fibrosis and type Ⅳ collagen serum levels also have a certain relationship, S2 increased, with S3 to S4 is the highest. The level of collagen Ⅳ was negatively correlated with prealbumin (r = 0.5321, P <0.01), but not with ALT and Sb. Conclusion The serum level of type Ⅳ collagen can better reflect the degree of liver fibrosis and provide a sensitive index for the early diagnosis of hepatic fibrosis.