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目的:观察显微镜联合神经内镜技术在颅底肿瘤切除术中的应用价值。方法:回顾性分析2016年7月至2020年7月苏州大学附属第一医院神经外科收治的100例颅底肿瘤患者的临床资料，其中50例采用显微镜联合神经内镜手术(双镜联合组)，50例仅采用显微镜手术(显微镜组)。双镜联合组、显微镜组在海绵窦区肿瘤患者中分别有30、24例，在岩斜区肿瘤患者中分别有12、16例，在枕骨大孔区肿瘤患者中分别有8、10例。分别比较3个部位的双镜联合组与显微镜组的手术时间、肿瘤全切除率，手术并发症、术后症状改善情况及肿瘤复发的差异。结果:与显微镜组比较，双镜联合组肿瘤的全切除比率或比例均高[海绵窦区分别为86.7%(26/30)、62.5%(15/24)，岩斜区分别为11/12、9/16，枕骨大孔区分别为7/8、4/10]；术后随访期[18~60个月(中位数为48个月)]肿瘤的复发比率或比例均低[海绵窦区分别为6.7%(2/30)、29.0%(7/24)，岩斜区分别为0/12、5/16，枕骨大孔区分别为1/8、7/10]，差异均有统计学意义(均n P<0.05)。术后1个月，海绵窦区和岩斜区肿瘤者中，双镜联合组临床症状的改善均优于显微镜组(均n P0.05)。n 结论:显微镜联合神经内镜技术能够提高颅底肿瘤的全切除率、降低复发率，并且不增加手术时间；在控制手术并发症方面与显微镜手术相近。“,”Objective:To explore the application value of microscopy combined with neuroendoscopy in skull base tumor resection.Methods:A retrospective analysis was conducted on the clinical data of 100 patients with skull base tumors admitted to the Department of Neurosurgery, the First Affiliated Hospital of Soochow University from July 2016 to July 2020. Among them, 50 patients were treated with microscopy combined with neuroendoscopy (dual-scopy group), and 50 patients underwent microsurgical operations only (microscopy group). There were 30 cases in the dual-scopy group and 24 cases in the microscopy group among the cavernous sinus tumor patients; there were 12 cases in the dual-scopy group and 16 cases in the microscopy group among the petroclival region tumor patients; there were 8 cases in the dual-scopy group and 10 cases in the microscopy group among the foramen magnum tumor patients. The differences in operation time, total tumor resection rate, surgical complications, postoperative symptom improvement, and tumor recurrence were analyzed between the dual-scopy group and the microscopy group of patients with tumors at three sites.Results:Compared with the microscopy group, the total tumor resection rate in the dual-scopy group was higher for the cavernous sinus tumors [86.7% (26/30) n vs. 62.5% (15/24)], petroclival region tumors (11/12 n vs. 9/16), and the foramen magnum tumors (7/8 n vs. 4/10). During postoperative follow-up period (range: 18-60 months, median: 48 months), the tumor recurrence rate in the dural-scopy group was lower than that in the microscopy group for the cavernous sinus tumors[6.7% (2/30) n vs. 29.0% (7/24)], petroclival region tumors (0/12 n vs. 5/16), and foramen magnum tumors (1/8 n vs. 7/10), and the differences were all statistically significant (all n P<0.05). At 1 month post operation, the dual-scopy group had more symptomatic improvement of clinical symptoms than microscopy group among the patients with tumors in the cavernous sinus and petroclival areas (bothn P0.05).n Conclusions:Microscopy combined with neuroendoscopy can improve the total resection rate of skull base tumors, reduce the recurrence rate, and dose not increase the operation time. The technique of dual-scopy is similar to microsurgery in controlling surgical complications.