在各种有关上鼓室型胆脂瘤的病因学说中,支持异种移植及化生学说的作者甚少。目前,以Turmarkin为代表的内陷学说及以Lange与Rüedi为代表的移行学说受到较多的支持,尤以Rüedi的学说更为普遍。此外,在动物实验方面,Berberich(1927)及其他学者成功地建立了实验性胆脂瘤。这些病因学方面的研究工作正在发展中。然而,多数实验均属继发于化脓性中耳炎的胆脂瘤。仅有Schr(?)er(1957),Rüedi(1959)及Steinbach(1978)报告了成功建立上鼓室型胆脂瘤的实验。但无详细的材料可查,因而这些报告不能满意地解释胆脂瘤的发展过程。作者放置人工材料于兔的中耳腔内以研究中耳的反应。开放实验动物的中耳骨泡,阻塞咽鼓管的鼓室端开口,但不伤及鼓膜。作者观察外耳道乳头状上皮侵入中耳腔并形成上皮珠。第一批 Among the various theories of causation about tympanic cholesteatoma, few support the doctrine of xenotransplantation and metaplasia. At present, the trap doctrine represented by Turmarkin and the transformative theory represented by Lange and Rüedi receive more support, especially Rüedi’s doctrine is more common. In addition, Berberich (1927) and others have successfully established experimental cholesteatoma in animal experiments. Research on these etiologies is under development. However, most of the experiments are cholesteatoma secondary to suppurative otitis media. Only Schröder (1957), Rüedi (1959), and Steinbach (1978) reported successful experiments in establishing tympanic cholesteatoma. However, no detailed information is available and therefore these reports do not satisfactorily explain the development of cholesteatoma. The authors place artificial materials in the middle ear cavity of rabbits to study the middle ear response. Open the middle ear bone of experimental animals, blocking the tympanic end of the eustachian tube opening, but does not hurt the tympanic membrane. The authors observed that the external auditory canal epithelium invades the middle ear cavity and forms epithelial beads. The first batch