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[目的]研究浒苔多糖对右旋葡聚糖硫酸钠(DSS)诱发的小鼠溃疡性结肠炎的防治效果。[方法]取健康昆明种雄性小鼠48只,随机分成A、B、C、D、E、F6组。A组自由饮用蒸馏水,其余各组自由饮用5%DSS7d,制造结肠炎模型。造模期间,A组不予任何处理;B、C组于造模第1、3、5、7d分别腹腔注射生理盐水、1mg/kg地塞米松;D、E、F组于造模前3、前1天,造模第1、3、5、7d分别腹腔注射2.5、5、10mg/ml浒苔多糖。计算各组小鼠的疾病活动指数(DAI)评分。[结果]B组的DAI评分高于A、C、D、E、F组,而A、C、D、E、F组的DAI评分两两比较,差异无统计学意义。[结论]浒苔多糖具有防治右旋葡聚糖硫酸钠致小鼠溃疡性结肠炎的作用。
[Objective] To study the effect of Enteromorpha polysaccharides on the prevention and treatment of mouse ulcerative colitis induced by dextran sodium sulfate (DSS). [Method] Forty-eight healthy Kunming male mice were randomly divided into A, B, C, D, E and F6 groups. Group A was allowed to drink distilled water, and the remaining groups were free to drink 5% DSS7d to make colitis model. Group A, Group C received no intraperitoneal injection of saline and 1 mg / kg dexamethasone on the 1st, 3rd, 5th and 7th day after modeling respectively. Before the model 3 , The first day before modeling 1,3,5,7 d were intraperitoneal injection 2.5,5,10 mg / ml Enteromorpha polysaccharides. Disease activity index (DAI) scores were calculated for each group of mice. [Results] The DAI scores in group B were higher than those in groups A, C, D, E and F, while the DAI scores in groups A, C, D, E and F were no significant difference. [Conclusion] Enteromorpha polysaccharides could prevent and cure ulcerative colitis induced by dextran sulfate in mice.