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Inactivation cross sections for haploid yeast cell strain211a have been calculated as 1-hit detector based on the tracktheory in an extended target mode and a numerical calculation ofradial dose distribution. In the calculations, characteristic dose D0 is a fitted parameter which is obtained to be 42 Gy, and "radius"of hypothetical target a0 is chosen to be 0.5μm which is about the sizeof nucleus of yeast cells for obtaining an overall agreement withexperimental cross sections. The results of the calculations are inagreement with the experimental data in high LET (linear energy transfer) including the thindown region.