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某些学者发现急性前部色素膜炎与HLA-B_(27)抗原有明显的关联,而与蛋白酶抑制因子α_1-抗胰蛋白酶表现型是否有关联却有不同看法。作者搜集7个芬兰家族的16名急性前部色素膜炎患者及28名亲属进行眼部检查,测定HLA-A、HLA-B、HLA-C、HLA-DR抗原及α_1-抗胰蛋白酶表现型,并以同地区之120名健康人作对照。发现16例患者的HLA-B_(27)出现率为100%,21名亲属之出现率为28.6%,对照组为14%。先证者与对照组有极显著性差异(P<0.0001)。HLA-Cwl的出现率,患者为64.3%,先证者为50%,亲属为23.8%,对照组为14%,先证者与对照组比较无统计学意义。15例患者蛋白酶抑制因子α_1-抗胰蛋白酶表现型出现率为6.7%,对照组为4.2%;
Some scholars have found that acute anterior uveitis is significantly associated with HLA-B27 antigen, but different from protease inhibitor alpha-1 antitrypsin phenotype. The authors collected 16 Finnish families of patients with acute anterior uveitis and 28 relatives of the eye examination, determination of HLA-A, HLA-B, HLA-C, HLA-DR antigen and α 1 -antitrypsin phenotype The comparison was made with 120 healthy people in the same district. We found 16 cases of HLA-B_ (27) incidence of 100%, 21 relatives of the incidence rate of 28.6% in the control group was 14%. There was a significant difference between probands and controls (P <0.0001). The prevalence of HLA-Cwl was 64.3% in patients, 50% in probands, 23.8% in relatives and 14% in controls. There was no significant difference between probands and controls. The incidence of protease inhibitor alpha 1-antitrypsin phenotype was 6.7% in 15 patients and 4.2% in control group.