帕金森氏病(PD)是发生在中老年期的一种常见的缓慢进展的神经系统疾病。主要由于黑质及黑质纹状体通路的变性,多巴胺(DA)含量的下降,出现震颤,肌强直及运动减少等临床症候群,由此引起患者生活质量的下降及生存年限的减低。近年来,本病的研究取得了长足进步。现将有关方面综述如下。 Parkinson’s disease (PD) is a common, slow-progressing neurological disorder that occurs in middle-aged and elderly people. Mainly due to the denaturation of the substantia nigra and nigrostriatal pathways, dopamine (DA) levels decline, there tremor, myotonia and decreased motion and other clinical syndromes, which led to the decline in the quality of life of patients and reduce the life span. In recent years, the study of this disease has made great strides. The relevant parties are summarized below.