肝内胆管细胞癌(intrahepatic cholangiocarcinoma,ICC),是指起源于肝内二级或以上的胆管上皮恶性肿瘤。其发病率约占原发性肝脏恶性肿瘤的5%~10%~([1-2]),仅次于肝细胞癌(hepaticarcinoma,HCC),且有逐年增高的趋势。虽然ICC与HCC同属于原发性肝癌(primary liver cancer,PLC),但是由于其具有病程短、进展快、诊断难、预后差等特点且在病理、临床分型、手术方式等方面两者存在显 Intrahepatic cholangiocarcinoma (ICC) refers to bile duct epithelial malignancies that originate in the liver at level two or above. The incidence of primary hepatic malignancies accounts for about 5% ~ 10% ~ ([1-2]), second only to hepatocellular carcinoma (HCC), and there is a trend of increasing year by year. Although both ICC and HCC belong to primary liver cancer (PLC), they are characterized by short course of disease, rapid progression, difficult diagnosis and poor prognosis, and both exist in pathology, clinical classification and operation mode Significantly