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盐酸氯环利嗪乳膏为长效抗组织胺新药,其作用持续时间一般为12～18 h,能有效地拮抗组织胺所致毛细血管扩张作用和支气管平滑肌的痉挛作用。常用于接触性皮炎、丘疹性荨麻疹、过敏性皮炎等症的治疗。BP 2000收载了盐酸氯环利嗪原料,含量测定用酸碱滴定电位法测定,但未收载其制剂。盐酸氯环利嗪乳膏收载于卫生部药品标准,其含量测定方法采用高氯酸非水滴定法,但因制剂中基质干扰,终点不明显,有关部门曾对
Chloraclidine hydrochloride cream long-acting antihistamine new drug, its duration of effect is generally 12 ~ 18 h, can effectively antagonize the histamine-induced telangiectasia and bronchial smooth muscle spasm. Commonly used in contact dermatitis, papular urticaria, atopic dermatitis embolism treatment. BP 2000 contains the raw material of chlorocyclizine hydrochloride, its content is determined by acid-base titration potentiometry, but its preparation is not contained. Chlorhexidine hydrochloride cream contained in the Ministry of Health drug standards, determination of the content of perchloric acid non-aqueous titration method, but the preparation of matrix interference, the end is not obvious, the authorities have on