硝基咪唑类药物对原虫感染疾病的高度活性,已经引起医药界的重视,近年来不断合成出新的化合物,作为抗原虫感染治疗药物,进行实验研究和临床。本类药物对阿米巴、滴虫、肠梨形鞭毛虫等原虫感染有高度活性。尤其对阿米巴的作用,不仅在于肠道,对其它部位如肝阿米巴及急慢性阿米巴病均有效。对于泌尿系统女性和男性滴虫感染,内服和外用均可,口服方便,副反应小,目前已成为抗阿米巴及滴虫病的主要药物。同类化合物能作用于体内不同部位,经不同程度的吸收、代谢和排泄过程,而取得不同效 The high activity of nitroimidazoles on protozoan infections has drawn the attention of the medical community. In recent years, new compounds have been continuously synthesized and used as anti-protozoal infections in experimental research and clinical trials. The class of drugs on amoeba, trichomoniasis, intestinal diarrhea flagellates and other protozoa highly active. In particular, the role of amoeba, not only in the intestine, other parts such as hepatic amoebiasis and acute and chronic amoebic disease are effective. For urinary system female and male trichomonas infection, oral and external use can be oral convenience, side effects, has become a major drug against amoebiasis and trichomoniasis. Similar compounds can act on different parts of the body, by varying degrees of absorption, metabolism and excretion process, and obtain different effects