子宫腺肌病多发生于30~50岁育龄期妇女,常见症状为月经过多、痛经、盆腔痛、子宫异常出血及宫体增大~([1-3])。子宫腺肌病在某些方面可表现出恶性特征,如血管生成和侵袭行为。子宫腺肌病在子宫内膜癌子宫切除标本中常见~([4])。子宫腺肌病可恶变为子宫内膜癌~([4])。本文就目前子宫腺肌病恶变的高危因素及病理机制的相关研究进行综述,并结合文献进展予以荟萃分析。1子宫腺肌病恶变发病率与临床表现 Adenomyosis often occurs in women of childbearing age 30 to 50 years old, common symptoms are menorrhagia, dysmenorrhea, pelvic pain, abnormal uterine bleeding and enlarged uterus (1-3). Adenomyosis in some aspects can show malignant features, such as angiogenesis and invasive behavior. Adenomyosis in hysterectomy specimens of endometrial cancer common ~ ([4]). Adenomyosis malignant endometrial cancer ~ ([4]). This article reviews the current research on the risk factors of malignant adenomyosis and the pathological mechanism of adenomyosis, and reviews the literature to make a meta-analysis. 1 adenomyosis malignant morbidity and clinical manifestations