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目的:探讨注射用奥美拉唑控制胃溃疡出血的临床效果。方法:收集我院2013年11月~2014年9月治疗的120例胃溃疡出血患者,随机分成观察组和对照组各60例,所有患者均按照医嘱调整饮食,对照组给予西咪替丁800mg,加酚磺乙胺静脉滴注,1次/d,连续治疗14d;观察组给予给予注射用奥美拉唑40mg+生理盐水100ml静脉滴注,2次/d,连续治疗14d。结果:经过治疗后观察组显效52例,显效率为86.7%,有效6例,有效率为10.0%,无效2例,总有效率为96.7%;对照组显效36例,显效率为60.0%,有效8例,有效率为13.3%,无效16例,总有效率为73.7%,两组比较有统计学意义(P<0.05),观察组随访1个月幽门螺旋杆菌阴转例数为38例,阴转率为77.6%,随访2个月幽门螺旋杆菌阴转例数为46例,阴转率为93.9%,随访3个月幽门螺旋杆菌阴转例数为48例,阴转率为97.9%,对照组随访1个月幽门螺旋杆菌阴转例数为17例,阴转率为34.7%,随访2个月幽门螺旋杆菌阴转例数为27例,阴转率为55.1%,随访3个月幽门螺旋杆菌阴转例数为29例,阴转率为59.2%,两组比较有统计学意义(P<0.05)。结论:注射用奥美拉唑治疗胃溃疡出血疗效显著,值得推广。
Objective: To investigate the clinical effect of omeprazole injection for gastric ulcer bleeding control. Methods: A total of 120 patients with gastric ulcer hemorrhage treated in our hospital from November 2013 to September 2014 were randomly divided into observation group (60 cases) and control group (60 cases). All patients were diet adjusted according to doctor’s advice. The control group was given cimetidine 800mg , Plus phenylethylamine sulphoxide intravenous infusion, 1 time / d, continuous treatment 14d; the observation group given omeprazole injection 40mg + saline 100ml intravenous infusion, 2 times / d, continuous treatment 14d. Results: After treatment, the observation group was effective in 52 cases, the effective rate was 86.7%, effective in 6 cases, the effective rate was 10.0%, 2 cases were ineffective, the total effective rate was 96.7%; 36 cases markedly effective in the control group, the effective rate was 60.0% Effective in 8 cases, effective rate was 13.3%, ineffective in 16 cases, the total effective rate was 73.7%, the two groups were statistically significant (P <0.05), the observation group was followed up for 1 month, H. pylori negative conversion rate of 38 cases . The negative conversion rate was 77.6%. During the two months follow-up, 46 cases of H. pylori negative conversion were found, and the negative conversion rate was 93.9%. During the 3 months follow-up, 48 cases of H. pylori negative conversion were found, and the negative conversion rate was 97.9 %. In the control group, the number of cases of H. pylori negative conversion was 17 cases and the negative conversion rate was 34.7% at 1 month after follow-up. The number of cases of H. pylori negative conversion was 27 cases at 2 months of follow-up, the negative conversion rate was 55.1% The number of cases of Helicobacter pylori negative conversion in one month was 29 and the negative conversion rate was 59.2%. There was a significant difference between the two groups (P <0.05). Conclusion: Omeprazole for the treatment of gastric ulcer bleeding significant effect, it is worth promoting.