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为评价泽泻乙酸乙酯部位对2型糖尿病的降血糖作用及其机制,采用高脂高糖饲料喂养大鼠4周后再腹腔注射小剂量链尿佐菌素(STZ)的方法,建立2型糖尿病大鼠模型。将糖尿病大鼠随机分为模型组、泽泻乙酸乙酯部位组(AREEA,20,50,100 mg/kg)、二甲双胍组(100 mg/kg)。连续给药4周后进行葡萄糖耐量和胰岛素耐量实验。于末次给药后禁食12 h,采血测定大鼠空腹血糖(GLU)、糖化血红蛋白(HbA1c)、胰岛素(Ins)以及胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)含量,脂肪组织中胰岛素信号通路IRS-1和Akt的磷酸化水平及胰脏的病理变化。结果显示,给药组大鼠的空腹血糖有明显降低(P<0.05);100 mg/kg组显著降低血清GLU、HbA1c、TC、TG、MDA、TNF-α、IL-6(P<0.05);明显升高SOD、GSH-Px(P<0.05)。这些结果提示泽泻乙酸乙酯部位可有效调节体内糖、脂代谢,对2型糖尿病有一定治疗作用。
In order to evaluate the hypoglycemic effect and mechanism of ethyl acetate part of Alisma orientalis on type 2 diabetes mellitus, rats were given high-fat and high-sugar diet for 4 weeks and then intraperitoneally injected with low-dose streptozotocin (STZ) Diabetic rat model. The diabetic rats were randomly divided into model group, Alismazole group (AREEA, 20, 50, 100 mg / kg) and Metformin group (100 mg / kg). After 4 weeks of continuous administration, glucose tolerance and insulin tolerance test were performed. Fasting blood glucose (GLU), glycosylated hemoglobin (HbA1c), insulin, cholesterol (TC), triglyceride (TG) and high density lipoprotein (HDL- (LDL-C), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), tumor necrosis factor- -α), interleukin-6 (IL-6), the phosphorylation of insulin signaling IRS-1 and Akt in adipose tissue and the pathological changes of pancreas. The results showed that fasting blood glucose was significantly decreased in the treatment group (P <0.05); serum GLU, HbA1c, TC, TG, MDA, TNF-α and IL- ; Significantly increased SOD, GSH-Px (P <0.05). These results suggest that the part of Alisma orientalis can effectively regulate the metabolism of sugar and lipid in the body and has a certain therapeutic effect on type 2 diabetes mellitus.