目的对司他夫定在不同溶液中的稳定性进行考察。方法在司他夫定的最大吸收波长处,采用紫外分光光度法分别测定了不同pH值的司他夫定溶液在36 h内不同时间的吸光度。结果司他夫定在不同pH值溶液中的稳定性不同。结论在12h内,司他夫定在pH7.4、pH6.8、pH 1.0的水溶液中基本稳定。符合在12 h内司他夫定在pH 7.4、pH 6.8、pH 1.0水溶液中溶出的体外分析方法要求。 Objective To investigate the stability of stavudine in different solutions. Methods At the maximum absorption wavelength of stavudine, the absorbance of stavudine solution with different pH values ​​at different time was measured by ultraviolet spectrophotometry. Results Stavudine has different stability in different pH solutions. Conclusion Stavudine is basically stable in pH7.4, pH6.8, pH 1.0 aqueous solution within 12 hours. In line with in 12 hours stavudine in pH 7.4, pH 6.8, pH 1.0 aqueous solution of in vitro analytical methods required.