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目的 :对实验性高脂血症大鼠血液流变学影响及其对大鼠的胚胎毒性和致畸作用。方法 :①用高脂饲料喂饲 10天以形成实验性高脂血症大鼠模型 ,同时经口灌胃给予 75、15 0mg·kg-1益脂平胶囊 2 0天 ,测定血液流变学的各项指标。②根据毒理学检测程序[1] ,实验组经口灌胃给予 2 5 0、5 0 0、10 0 0mg·kg-1益脂平胶囊 ,观察其对大鼠的胚胎毒性及致畸作用。结果 :①益脂平胶囊能显著增加实验性高脂血症模型大鼠的红细胞电泳率、显著降低实验性高脂血症模型大鼠的红细胞沉降率 (P <0 .0 5 ) ;能降低实验性高脂血症模型大鼠的全血粘度和血浆粘度 (P <0 .0 5 ) ;②与对照组比较 ,益脂平胶囊实验组孕鼠未见体重增长显著减慢、活产仔数显著减少、死胎率及吸收胎率显著增加以及未见胎仔平均体重、体长、尾长发育指标显著减缓和外观畸形与骨骼畸形明显增加。结论 :①益脂平胶囊可以改善实验性高脂血症大鼠血液流变学指标 ;②在本试验剂量与条件下益脂平胶囊无母体毒性、胚胎毒性和致畸作用
Objective: To study the hemorheology of rats with experimental hyperlipidemia and its effects on embryotoxicity and teratogenicity in rats. Methods: 1 High-fat diet was fed for 10 days to form experimental hyperlipidemia rat model. At the same time, 75, 150 mg·kg-1 Yizhiping capsules were given by oral gavage for 20 days to determine hemorheology. The various indicators. 2 According to the toxicological testing procedures [1], the experimental group was orally administered 250, 500, and 1000 mg·kg-1 Yizhiping capsules orally to observe its embryotoxicity and teratogenic effects in rats. RESULTS: 1 Yizhiping capsule can significantly increase the electrophoretic rate of red blood cells in experimental hyperlipidemia model rats, significantly reduce the erythrocyte sedimentation rate in experimental hyperlipidemia model rats (P < 0.05), and can reduce Whole blood viscosity and plasma viscosity of experimental hyperlipidemia model rats (P < 0.05); 2 Compared with the control group, no significant weight gain was observed in the pregnant mice of the Yizhiping capsule experimental group, and live births were not observed. Significant reduction in number, stillbirth rate, and absorptive fetus rate were significantly increased, as well as no significant reductions in fetal weight, body length, and tail length development indicators, and apparent malformations and skeletal abnormalities. Conclusion :1 Yizhiping capsule can improve the hemorheology of experimental hyperlipidemic rats;2 No fat, embryo toxicity and teratogenic effects of Yizhiping capsule under the dose and condition of this experiment.