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本研究旨在观察服用ＲＵ４８６及米索前列醇作为每月一次避孕药的有效性、安全性和可接受性。共接纳２４例对象，观察了８４个周期。用药方案为：预期月经来潮前一日服用ＲＵ４８６２００ｍｇ，４８ｈ后在家中服用米索前列醇４００μｇ。结果显示，妊娠率约为２２．６２％。１９个妊娠周期中有１３个周期完全流产（６８．４２％），２个周期不全流产（１０．５３％），４个周期继续妊娠（２１．０５％）。８４个观察周期中有６个周期出现２次阴道流血，１个周期出现３次阴道流血，７个周期出现周期延长。２４例对象中仅１例因乏力、嗜睡影响工作和生活而退出研究，其余仅极个别对象有恶心、下腹部疼痛、手麻等副反应，但都无需治疗。结果表明用本方案作为每月一次避孕药的效果和可接受性并不理想。
This study aimed to observe the efficacy, safety and acceptability of RU486 and misoprostol as monthly contraceptives. A total of 24 subjects were enrolled and 84 cycles were observed. The medication regimen is: RU486200mg expected on the first day of menstrual cramps, 400μg misoprostol at home after 48h. The results showed that the pregnancy rate was about 22.62%. Thirteen cycles of pregnancy were completely aborted (68.42%), two cycles of incomplete abortion (10.53%) and four cycles of continued pregnancy (21.05%). There were 6 vaginal bleeding in 6 cycles in 84 observation periods, 3 vaginal bleeding in 1 cycle, and extended cycle in 7 cycles. Only one of the 24 subjects left the study because of fatigue and drowsiness, which affected their work and life. The other subjects only had nausea, abdominal pain and side effects such as hand numbness, but they did not need treatment. The results show that the use of this program as a monthly contraceptive effect and acceptability is not ideal.