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川崎病(KD)约20％发生冠状动脉损害,常规用药阿司匹林(ASP)有抗炎抗凝功能,但没有预防和减少冠状动脉病变(CAD)的作用。近年来国内外报道用大剂量免疫球蛋白(IVIG)可明显降低冠状动脉的发生率及严重程度。亦有人提出用1g/kg剂量可以发挥其满意疗效。现将我院单用ASP与IVIG+ASP治疗本病进行对比研究,了解1g/kg剂量IVIG临床疗效及预防CAD发生的作用。
Coronary artery lesions occur in about 20% of KD patients. Conventional aspirin (ASP) has anti-inflammatory and anticoagulant effects but does not prevent and reduce coronary artery lesions (CAD). In recent years, large dose of immunoglobulin (IVIG) reported at home and abroad can significantly reduce the incidence and severity of coronary artery. It has also been suggested that with 1g / kg dose can play its satisfactory effect. Now our hospital with ASP and IVIG + ASP treatment of the disease compared to study 1g / kg dose IVIG clinical efficacy and prevention of the role of CAD.