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目的研究山东内陆地区≥20岁居民血尿酸(血清尿酸,SUA)水平、高尿酸血症(hyperuricemia,HUA)的流行及其影响因素。方法采用随机、分层抽样方法选取2012年1月~2012年12月期间11 234例健康查体人群,询问既往史和个人史,测量身高、体质量和血压,检测肝功、肾功和生化等指标。多元线性回归分析相关变量对SUA的影响程度,logistic回归分析HUA的危险因素。结果 HUA的患病率为15.71%,男、女性患病率分别为18.89%、6.31%。男性年龄>50岁组SUA水平和HUA患病率均低于男性<50岁组,女性HUA患病率随着年龄增加而升高,各年龄组内男性SUA水平均高于女性(P<0.001),20~34岁、35~49岁、50~64岁3个年龄组男性HUA的患病率均高于女性,>64岁组女性HUA的患病率高于男性。血肌酐(SCr)对男女性SUA影响最大(β男=0.229、β女=0.200)。饮酒、甘油三酯(TG)、肥胖、高血压、BCr、血尿素氮(BUN)、丙氨酸转氨酶(ALT)和谷氨酰转肽酶(GGT)是男性HUA患病的独立危险因素,高血压、TG、低密度脂蛋白、BCr、BUN、ALT与女性HUA密切相关。结论山东内陆地区居民HUA患病率较高,饮酒、肥胖、高血压、血脂异常、肝功和肾功指标异常等都增加HUA发病风险,因此减少饮酒,控制体质量、血压等对预防HUA极为重要。
Objective To investigate the prevalence of serum uric acid (SUA), hyperuricemia (HUA) and its influencing factors in ≥20 years old residents in Shandong inland areas. Methods A total of 11,234 healthy people from January 2012 to December 2012 were selected by random and stratified sampling method. The past history and personal history were surveyed. Height, body mass and blood pressure were measured. Liver function, kidney function and biochemistry And other indicators. Multivariate linear regression analysis of the impact of variables on SUA, logistic regression analysis of risk factors for HUA. Results The prevalence of HUA was 15.71%. The prevalence rate of HUA was 18.89% and 6.31% respectively. The prevalence of SUA and prevalence of HUA were lower in men> 50 years old than those in men <50 years old. The prevalence of HUA in women increased with age, and the SUA in men was higher than that in women (P <0.001) ). The prevalence rates of HUA in males aged 20-34, 35-49 and 50-64 years were higher than those in females. The prevalence of HUA in females> 64 years old was higher than that of males. Serum creatinine (SCr) had the greatest effect on male and female SUA (β = 0.229, β = 0.200). Alcohol consumption, triglyceride (TG), obesity, hypertension, BCr, blood urea nitrogen (BUN), alanine aminotransferase (ALT) and glutamyl transpeptidase (GGT) were independent risk factors for HUA in men, Hypertension, TG, low density lipoprotein, BCr, BUN, ALT and female HUA are closely related. Conclusion The prevalence of HUA is higher in residents in Shandong inland areas, and the risk of HUA is increased due to alcohol consumption, obesity, hypertension, dyslipidemia, abnormal liver function and renal function. Therefore, reducing HUA Extremely important.