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作者根据临床所见,总结出下列几种骨髓转移瘤特殊表现:(1)以弥散性血管内凝血(DIC)为首发表现。恶性肿瘤易并发DIC,机理可能是:①瘤细胞含有大量组织凝血活酶样促凝物质进入循环;②恶性肿瘤患者常伴高纤维蛋白原血症;③肿瘤细胞对血管壁的破坏;④瘤细胞坏死释放出组织因子或瘤细胞转移至血循环内形成粗颗粒,激活血管内皮,诱发DIC。(2)以低血钙为主要表现。发病机理:①肿瘤可分泌降钙素,使血钙降低;②肿瘤侵犯肾脏
According to the clinical findings, the authors summarized the following special manifestations of bone marrow metastases: (1) disseminated intravascular coagulation (DIC) as the first performance. Malignant tumors complicated by DIC, the mechanism may be: ① tumor cells contain a large number of tissue thromboplastin-like procoagulant substances into circulation; ② patients with malignant tumors often accompanied by hyper fibrinogen; ③ tumor cells on the destruction of the vessel wall; Cell necrosis releases tissue factor or tumor cells to the blood circulation to form coarse particles, activate the vascular endothelium, induced DIC. (2) low calcium as the main performance. Pathogenesis: ① tumor can secrete calcitonin, so that serum calcium decreased; ② tumor invasion of the kidney