论文部分内容阅读
目的:通过观察心肌组织和血浆内皮素(ET)、血管紧张素Ⅱ(Ang Ⅱ)含量的变化,研究愈心梗液防治急性心肌梗死(AMI)后心室重构的机理。方法:结扎 Wistar 大鼠冠状动脉左前降支,体表心电图Ⅱ导示 ST-T 弓背抬高,证实 AMI 形成后,将大鼠随机分为6组,于手术后第2天开始灌胃给药,连续4周。然后处死大鼠,观察各组大鼠心脏指数、心室重量和心肌组织及血中 ET、Ang Ⅱ含量。结果:与模型组比较,愈心梗液大、中剂量和开博通皆可显著降低 AMI 大鼠心脏指数(P<0.01)和左室重量,愈心梗液大剂量和开搏通可显著降低心肌组织及血浆中 ET、AngⅡ含量(P<0.01和P<0.05)。愈心梗液中、小剂量亦能明显降低心肌组织中 ET 的含量(P<0.05)。结论:愈心梗液可显著降低 AMI 大鼠左室重量和心脏指数,其降低心肌组织及血浆中 ET 和 AngⅡ的含量可能是防治 AMI 后期心室重构的作用机理之一。
OBJECTIVE: To study the mechanism of prevention and treatment of ventricular remodeling after acute myocardial infarction (AMI) by observing changes in myocardial tissue and plasma endothelin (ET) and angiotensin II (Ang II) content. METHODS: The left anterior descending coronary artery of Wistar rats was ligated, and the surface ECG II showed ST-T elevation. After confirming the formation of AMI, the rats were randomly divided into 6 groups, and the rats were given intragastric administration on the 2nd day after surgery. Medicine for 4 weeks. Then, the rats were sacrificed and the cardiac index, ventricular weight, myocardial tissue, and blood ET and Ang II contents were observed in each group. RESULTS: Compared with the model group, the HMI, middle dose and Kaiborong could significantly reduce the heart index (P<0.01) and left ventricular weight in AMI rats. Significant doses of Yuxinyeye liquid and Kaifutong could be significantly reduced. The content of ET and Ang II in myocardial tissue and plasma was decreased (P<0.01 and P<0.05). The concentration of ET in myocardium tissue was also significantly decreased in the medium and low doses of Yuxinxin (P<0.05). Conclusion: Yuxinhuye liquid can significantly reduce left ventricular weight and cardiac index in AMI rats, and decreasing the content of ET and AngII in myocardial tissue and plasma may be one of the mechanisms of prevention and treatment of ventricular remodeling in late AMI.