转录因子是一类核蛋白因子,其功能是调节基因的转录表达.有关转录因子的结构—功能关系是目前分子生物学研究的热点之一.在人类白血病中,有多种基因异常可累及转录因子,从而可能使造血细胞分化、增殖过程发生紊乱,在白血病的发病机理中起着重要的作用. Transcription factor is a kind of nucleoprotein factor whose function is to regulate the transcription and expression of genes. The structure-function relationship of transcription factors is one of the hot spots in molecular biology research. In human leukemia, there are many kinds of gene abnormalities that can affect transcription. Factors, which may make the hematopoietic cell differentiation and proliferation process disorder, play an important role in the pathogenesis of leukemia.