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测定了急性心肌梗塞(AMI)20例患者血浆组织型纤溶酶原激活物(t-PA)及抑制物(PAI)的活性变化,并对11例尿激酶(UK)治疗的患者进行了上述指标的动态观察。结果:心肌梗塞组与正常组比较,血浆t-PA活性无变化,PAI活性显著升高(P<0.001);UK治疗前后观察,通过方差分析,上述指标差异非常显著。结果提示:PAI在血栓形成中有重要的病理意义;UK溶栓治疗能够改善机体自身纤溶系统的稳定性。
The changes of plasma tissue-type plasminogen activator (t-PA) and inhibitor (PAI) in 20 patients with acute myocardial infarction (AMI) were measured. Eleven patients with urokinase (UK) Dynamic observation of indicators. Results: Plasma t-PA activity did not change and PAI activity was significantly increased in the myocardial infarction group compared with the normal group (P <0.001). Before and after the UK treatment, variance was used to analyze the above indexes. The results suggest that: PAI in thrombosis has important pathological significance; UK thrombolytic therapy can improve the body’s own fibrinolytic system stability.