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目的观察壮骨1号方的镇痛抗炎作用,为临床研究提供科学依据。方法采用小鼠热板、醋酸扭体两种镇痛实验方法,观察壮骨1号方的镇痛作用;采用小鼠二甲苯耳肿模型和大鼠棉球肉芽肿模型,观察壮骨1号方的抗炎作用。结果壮骨1号方能有效地缓解由外界热刺激和化学性刺激引起的机体的疼痛,具有较好的镇痛作用,尤以高、中剂量效果显著;能有效的降低小鼠、大鼠的急性炎症和慢性炎症的发生,具有较好的抗炎效果。结论壮骨1号方具有显著的镇痛和抗炎效果。
Objective To observe the analgesic and anti-inflammatory effects of Zhuanggu 1 Prescription and provide a scientific basis for clinical research. Methods The analgesic effects of Zhuanggu 1 Prescription were observed by two kinds of analgesic methods: hot plate of mice and acetic acid writhing. The mice models of xylene ear swelling and rat granuloma were observed, Anti-inflammatory side effects. Results Zhuanggu No.1 can effectively relieve body pain caused by external thermal and chemical stimuli, and has good analgesic effect, especially in high and medium dose. It can effectively reduce the weight of mice, rats Of acute inflammation and chronic inflammation, has a good anti-inflammatory effect. Conclusion Zhuanggu 1 Prescription has significant analgesic and anti-inflammatory effects.