已有研究表明慢性乙型肝炎与糖尿病密切相关,可引起血糖异常,甚至诱发糖尿病,其发生机制与胰岛素抵抗、肝功能受损、肝脂肪变、乙型肝炎病毒在胰腺复制、胰腺损伤及自身免疫反应、干扰素的应用等相关。反之,胰岛素抵抗及糖尿病亦可加速慢性乙型肝炎进展为肝纤维化及肝癌。现就慢性乙型肝炎与糖尿病关系的研究进展予以综述。 Studies have shown that chronic hepatitis B is closely related to diabetes, which can cause abnormal blood glucose and even induce diabetes. Its mechanism of occurrence and insulin resistance, impaired liver function, hepatic steatosis, hepatitis B virus replication in the pancreas, pancreatic injury and its own Immune response, the application of interferon and so on. Conversely, insulin resistance and diabetes can also accelerate the progression of chronic hepatitis B to liver fibrosis and liver cancer. Now on the research progress of chronic hepatitis B and diabetes mellitus are reviewed.