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目的制备和评价α-常春藤皂苷-丙烯酸树脂Eudragit L100纳米粒(SPD-L100-NPs)。方法采用改良乳化-溶剂扩散法制备纳米粒,以粒径大小、包封率(EE)和多分散指数(PI)为指标,通过单因素试验和正交试验设计优化制备工艺。通过红外光谱、X射线衍射、差示扫描量热分析、体外释放试验等对纳米粒的相关性质进行评价。结果所制备的纳米粒外观圆整,平均粒径为(65.2±1.6)nm,EE为(99.13±0.20)%,PI值为0.384±0.008。药物在纳米粒中均被载体材料有效包裹,其体外释放具有显著的pH依赖性。结论采用改良乳化-溶剂扩散法可制备出包封率高、大小均匀的pH依赖性纳米粒。
Objective To prepare and evaluate the α-ivy saponin-acrylic resin Eudragit L100 nanoparticles (SPD-L100-NPs). Methods Nanoparticles were prepared by a modified emulsion-solvent diffusion method. The particle size, entrapment efficiency (EE) and polydispersity index (PI) were used as indexes to optimize the preparation process by single factor test and orthogonal design. The relevant properties of the nanoparticles were evaluated by infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, in vitro release test and the like. Results The prepared nanoparticles showed a round appearance with an average diameter of (65.2 ± 1.6) nm, EE of (99.13 ± 0.20)% and a PI value of 0.384 ± 0.008. The drug is effectively encapsulated in the nanoparticle by the carrier material and has a significant pH dependence in vitro release. Conclusion The pH-dependent nanoparticles with high encapsulation efficiency and uniform size can be prepared by the modified emulsion-solvent diffusion method.