论文部分内容阅读
目的探讨脑热清(NRQ)口服液的解热机制。方法复制内生致热原性发热家兔模型,观察NRQ对体温的影响,并利用放射免疫法检测下丘脑及脑脊液cAMP的含量。结果NRQ对家兔内生致热原性发热有显著的解热作用(P<001);能够明显降低下丘脑及脑脊液中cAMP的含量(P<001)。相关分析显示,4组家兔的体温变化与下丘脑cAMP含量呈明显正相关(r=0899,P<001);下丘脑与脑脊液cAMP含量变化亦呈显著正相关(r=0971,P<001)。结论抑制下丘脑和脑脊液中cAMP含量的升高,可能是脑热清的解热机制之一。
Objective To investigate the antipyretic mechanism of NRQ oral solution. METHODS: Endogenous pyrogenic fever rabbit model was replicated. The effect of NRQ on body temperature was observed. The levels of cAMP in hypothalamus and cerebrospinal fluid were detected by radioimmunoassay. RESULTS: NRQ had significant antipyretic effects on endogenous pyrogenic fever in rabbits (P < 001) and significantly decreased cAMP content in hypothalamus and cerebrospinal fluid (P <0.001). Correlation analysis showed that there was a positive correlation between changes in body temperature and cAMP content in the hypothalamus between the four groups (r=0899, P<001); there was also a significant positive correlation between changes in cAMP content in the hypothalamus and cerebrospinal fluid (r=0971, P<001). ). Conclusion The inhibition of elevated cAMP levels in the hypothalamus and cerebrospinal fluid may be one of the mechanisms of antipyretic effect of Naoqingqing.