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A novel bioactive and bioresorbable PDLLA/chondroitin sulfate/chitosan scaffold was prepared via layer-by-layer(LBL)electrostatic-self-assembly(ESA)and the thermally induced phase separation (TIPS)technique.Chondroitin sulfate and chitosan were alternately deposited on the activated PDLLA substrate. The deposition process was monitored by UV-Vis absorbance spectroscopy.After frozen and lyophilized,the scaffold was characterized by attenuated total reflection(ATR)-FT-IR,XPS,SEM and AFM.The results showed that the scaffold was modified uniformly with a dehse inner layer with few detectable pores and a porous sponge outer layer with the pore size about 5μm,there was an obvious across section and the average thickness of each layer was about 9.4 nm.
A novel bioactive and bioresorbable PDLLA / chondroitin sulfate / chitosan scaffold was prepared via layer-by-layer (LBL) electrostatic-self-assembly (ESA) and the thermally induced phase separation (TIPS) technique. Chondroitin sulfate and chitosan were alternately deposited on the activated process was monitored by UV-Vis absorbance spectroscopy. After frozen and lyophilized, the scaffold was characterized by attenuated total reflection (ATR) -FT-IR, XPS, SEM and AFM. The results showed that the scaffold was modified uniformly with a dehse inner layer with few detectable pores and a porous sponge outer layer with the pore size about 5 μm, there was an obvious across section and the average thickness of each layer was about 9.4 nm.