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以形态学、芽管试验、血清学方法对88株临床致病念珠菌株进行了分类鉴定,对比随机扩增多态性DNA-聚合酶链反应的带型进行分析。分析结果表明,白念珠菌仍然是最常见的致病念珠菌,但存在着一种菌种变迁趋势,热带念珠菌和近平滑念珠菌的分离率合计约与白念珠菌的分离率相等,呈明显上升趋势。这种趋势除对治疗具有重要的指导作用外,还提示我们应发展更好的抗真菌药物。文中还对各种鉴定的方法进行了评估。
Eighty clinically pathogenic Candida strains were classified and identified by morphological, germ tube test and serological methods, and the bands of random amplified polymorphic DNA-polymerase chain reaction were analyzed. The results showed that Candida albicans was still the most common pathogenic Candida, but there was a trend of strain change. The isolation rate of Candida tropicalis and Candida parapsilosis was about the same as that of Candida albicans Significant upward trend. This trend, besides having an important guiding effect on treatment, also prompts us to develop better antifungal drugs. The article also evaluated various methods of identification.