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研究一种加速方法以考察胸腺五肽微球的体外释放。采用复乳-液中干燥法,以乳酸-羟基乙酸共聚物(PLGA)为成球材料制备胸腺五肽微球。在较高的温度(45°C,50°C和55°C)条件下,对胸腺五肽微球进行体外加速释放,并且与37°C时常规释放的结果进行比较。在较高的温度(45°C,50°C和55°C)条件下,实现了胸腺五肽微球的加速释放。特别是在50°C条件下,能够在30h内预测37°C时常规释放30d的释放度水平,而且相关性良好。调整释放条件,可以采用加速释放的方法评价胸腺五肽微球的体外释放。
An accelerated method was investigated to investigate the in vitro release of thymopentin microspheres. The double-emulsion-liquid drying method was used to prepare thymopentin microspheres with lactic acid-glycolic acid copolymer (PLGA) as the spherulite material. Thymopentin microspheres were accelerated in vitro at higher temperatures (45 ° C, 50 ° C and 55 ° C) and compared to the results of routine release at 37 ° C. Accelerated release of thymopentin microspheres was achieved at higher temperatures (45 ° C, 50 ° C and 55 ° C). Especially in the 50 ° C conditions, can be predicted within 30h 37 ° C release level of 30d conventional release, and the correlation is good. Adjust the release conditions, you can use accelerated release of thymopentin microspheres in vitro release evaluation.