论文部分内容阅读
[目的]了解静脉吸毒人群前瞻性研究队列3年随访的HIV血清抗体阳转率和队列保持率情况。[方法]于2002年11月,在四川省西昌市从社区招募了HIV血清抗体阴性的静脉吸毒人群前瞻性研究队列333人,队列每6个月随访1次并采集血样进行HIV抗体检测,以及分析队列本底的社会人口学和HIV高危行为特征与队列保持率的关系。[结果]静脉吸毒人群研究队列3年随访的HIV新发感染率为2.26/100人年(95%CI:1.08～3.45)和保持率为68.8%(229/333)。在多因素logistic回归模型分析中,与队列保持率的关系有统计学意义的变量为:彝族(OR:0.35;95%CI:0.21～0.59;P﹤0.0001)、6个月回访(OR:3.10;95%CI:1.81～5.31;P﹤0.0001)和近3个月静脉吸毒频率高(OR:1.79;95%CI:1.00～3.19;P=0.0485)。[结论]本研究结果表明该地区静脉吸毒人群HIV新发感染率较高,彝族和6个月未随访到的静脉吸毒人群队列保持率低。
[Objective] To understand the positive rates of HIV seroconversion and cohort maintenance in 3-year follow-up of prospective study cohorts of intravenous drug users. [Methods] A prospective cohort of 333 HIV-seronegative intravenous drug users was recruited from the community in Xichang, Sichuan Province in November 2002. The cohorts were followed up every 6 months and blood samples were collected for HIV antibody testing. Analyze the relationship between cohort demographic and socio-demographic characteristics of HIV high-risk behavior and cohort maintenance. [Results] The rate of new HIV infection was 2.26 / 100 years (95% CI: 1.08 ~ 3.45) and the retention rate was 68.8% (229/333) in the study drug cohorts. In the multivariate logistic regression model, variables with a statistically significant correlation with cohort retention were Yi (OR: 0.35; 95% CI: 0.21-0.59; P <0.0001), and a 6-month follow-up ; 95% CI: 1.81-5.31; P <0.0001) and frequency of intravenous drug abuse in the recent 3 months (OR: 1.79; 95% CI: 1.00-3.19; P = 0.0485). [Conclusion] The results of this study indicate that the rate of new HIV infection in the population of intravenous drug users in this area is high, and that of the Yi and 6-month non-follow-up intravenous drug users are low.