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目的:观察戊酸雌二醇联合阿司匹林对克罗米芬促排卵周期子宫内膜容受性的影响。方法:将本院75例排卵障碍性不孕症患者随机分为克罗米芬组(C组)、克罗米芬+戊酸雌二醇组(CE组)和克罗米芬+戊酸雌二醇+阿司匹林组(CEA组),每组各25例,观察3组患者HCG日子宫内膜厚度、子宫内膜类型、子宫动脉搏动指数(PI)、子宫动脉血流阻力指数(RI);排卵后7 d子宫内膜厚度、PI、RI,临床妊娠率及不良反应。结果:CE组和CEA组HCG日子宫内膜厚度、A型内膜率、排卵后7 d子宫内膜厚度显著高于C组,CEA组的PI值和RI值低于C组和CE组,CEA组临床妊娠率高于C组和CE组,而不良反应显著低于C组和CE组,差异有统计学意义(P<0.05)。结论:戊酸雌二醇能改善克罗米芬诱导排卵中子宫内膜的发育,与小剂量阿司匹林合用时,通过加强子宫血流灌注,改善子宫内膜的容受状态,降低不良反应并提高临床妊娠率。
Objective: To observe the effect of estradiol valerate combined with aspirin on the endometrial receptivity of clomiphene and ovulation induction period. Methods: Seventy-five patients with ovulatory failure of infertility were randomly divided into clomiphene citrate group (C group), clomiphene citrate group (estradiol acetate group) and clomiphene citrate group (estradiol valerate + aspirin group) (CEA group), 25 cases in each group. Endometrial thickness, endometrial thickness, endometrial thickness, uterine arterial pulse index (PI) and uterine artery blood flow resistance index (RI) were observed in 3 groups. Intima thickness, PI, RI, clinical pregnancy rate and adverse reactions. Results: Endometrial thickness, type A endometrial thickness, endometrial thickness at 7 days after ovulation in CE group and CEA group were significantly higher than those in C group. PI and RI values in CEA group were lower than those in C group and CE group, The clinical pregnancy rate of CEA group was higher than that of C group and CE group, but the adverse reaction was significantly lower than that of C group and CE group (P <0.05). Conclusion: Estradiol valerate can improve the development of endometrium induced by clomiphene in ovulation. When combined with low dose of aspirin, uterine blood flow perfusion can be improved to improve endometrial receptivity, reduce adverse reactions and improve clinical pregnancy rate.