论文部分内容阅读
目的:探讨妊娠期高血压疾病患者超敏C反应蛋白(hs-CRP)、尿微量白蛋白(mALB)水平及临床意义,为妊娠期高血压疾病的预测和诊断提供依据。方法:选择在吉林省妇幼保健院妇产科住院的138例孕妇为研究对象。根据罹患疾病及病情严重程度的不同将其分为子痫前期组(64例)、子痫组(28例)和对照组(无妊娠期高血压疾病的健康产妇,46例)。检测各组产妇hs-CRP、mALB等指标。结果:子痫前期组、子痫组和对照组hs-CRP、mALB水平比较,差异具有统计学意义(P<0.01);轻度子痫前期组和重度子痫前期组hs-CRP、mALB水平比较,差异有统计学意义(均P<0.01)。重度子痫前期合并并发症组与无并发症组hs-CRP、mALB水平比较,差异有统计学意义(P均<0.01)。妊娠期高血压疾病患者血清hs-CRP水平与尿mALB水平程正相关(r=0.618,P<0.01)。结论:血清hs-CRP和尿mALB与妊娠期高血压疾病密切相关。因此临床可通过监测血清hs-CRP水平、尿mALB水平来预测和预防妊娠期高血压疾病的发生。
Objective: To investigate the levels of hs-CRP and mALB in patients with gestational hypertension and provide the basis for the prediction and diagnosis of hypertensive disorders in pregnancy. Methods: 138 pregnant women who were hospitalized in the obstetrics and gynecology department of Jilin Provincial Maternal and Child Health Hospital were selected as the research object. The patients were divided into preeclampsia group (64 cases), eclampsia group (28 cases) and control group (healthy maternal without hypertensive disorder of pregnancy, 46 cases) according to the disease and the severity of the disease. Detection of maternal hs-CRP, mALB and other indicators. Results: The levels of hs-CRP and mALB in preeclampsia, eclampsia and control groups were significantly different (P <0.01). The levels of hs-CRP and mALB in mild preeclampsia and severe preeclampsia The differences were statistically significant (all P <0.01). The levels of hs-CRP and mALB in severe preeclampsia complication group and non-complication group were significantly different (all P <0.01). Serum hs-CRP level in patients with gestational hypertension was positively correlated with urinary mALB level (r = 0.618, P <0.01). Conclusion: Serum hs-CRP and urinary mALB are closely related to hypertensive disorder complicating pregnancy. Therefore, clinical monitoring of serum hs-CRP levels, urinary mALB levels to predict and prevent pregnancy-induced hypertension disease.