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本文著者用碘量滴定法初步观测了53名和52名我国正常男、女成人及31例妇科癌肿患者的全血谷胱甘肽含量。三组的全血谷胱甘肽总量分别为41.5±0.74,38.3±0.74和32.6±1.20毫克％。男、女成人的该测定值相差显著,但他们的全血氧化型或还原型谷胱甘肽含量则否。与正常女性组比较,妇科癌肿患者的全血谷胱甘肤总量及其还原型含量均呈明显降低,而氧化型谷胱甘肽则明显升高。正常人组的红细胞计数和全血谷胱甘肽总量无明显相关,而妇科癌肿患者则有极显著的正相关。另外,还用Scholander与Roughton 微量分析法观测了46名和47名我国正常男、女成人及31例妇科癌肿患者的全血氧容量,三组结果分别为19.2±0.25,16.8±0.26和12.8±0.61毫升％;发现正常男女之间以及妇科癌肿患者与正常女性之间均有明显差异。 对上述变化的可能机制,作了一些初步讨论。
The authors used iodometric titration method to preliminary observation of 53 and 52 of our normal male and female adults and 31 cases of gynecologic cancer patients with whole blood glutathione content. Total glutathione levels in the three groups were 41.5 ± 0.74, 38.3 ± 0.74 and 32.6 ± 1.20 mg%, respectively. The measurements for men and women differed significantly, but their levels of whole blood oxidized or reduced glutathione were not. Compared with the normal female group, the total amount of glutathione and its reduced content in the whole blood of patients with gynecological cancer were significantly decreased, while the oxidized glutathione was significantly increased. There was no significant correlation between erythrocyte count and whole blood glutathione in normal subjects, but significant positive correlation between gynecologic cancer patients and normal controls. In addition, the whole blood oxygen capacity of 46 and 47 gynecological cancer patients in 46 and 47 normal gynecologic cancer patients was also observed by Scholander and Roughton microdialysis. The results of the three groups were 19.2 ± 0.25, 16.8 ± 0.26 and 12.8 ± 0.61 ml%; found significant differences between normal men and women and between women with gynecologic cancer and normal women. The possible mechanisms for the above changes, made some preliminary discussions.