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利用γ射线辐照在聚乳酸膜表面接枝亲水性的聚N-乙烯基吡咯烷酮(PVP)来改善材料的亲水性和细胞相容性,用红外光谱(FTIR)、扫描电镜(SEM)、差示量热扫描仪(DSC)对接枝前后的聚乳酸膜进行测试,并利用接触角和吸水率分析了聚乳酸膜亲水性的变化。结果表明,接枝的PVP可以改善材料的亲水性,接枝率为16.4%的接枝共聚物吸水率较纯PLA提高了13.3倍,接触角下降了8°;细胞毒性实验结果表明,改性后的接枝共聚物无细胞毒性,并且与聚乳酸的浸提液细胞存活率101.9%相比,接枝共聚物体积分数50%和100%的浸提液的细胞存活率分别为109.3%和107.4%,表明接枝后的材料具有良好的细胞相容性,且更有利于细胞的生长。
Poly (N-vinyl pyrrolidone) (PVP) grafted on the surface of poly (DL-lactic acid) membrane by γ-ray irradiation was used to improve the hydrophilic and cytocompatibility of the material. FTIR, SEM, The differential scanning calorimetry (DSC) was used to test the polylactic acid film before and after grafting. The hydrophilicity of polylactic acid film was analyzed by using the contact angle and water absorption. The results showed that the grafted PVP could improve the hydrophilicity of the material. The water absorption of graft copolymer with graft ratio of 16.4% was 13.3 times higher than that of pure PLA and the contact angle decreased by 8 °. The cytotoxicity test showed that The post-graft copolymer was cytotoxic, and the cell viability of the extract at 50% and 100% of the graft copolymer was 109.3% compared with 101.9% of the cell survival rate of the polylactic acid leaching solution, respectively And 107.4% respectively, indicating that the grafted material has good cell compatibility and is more conducive to cell growth.