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目的探讨艾滋病病毒-1型(HIV-1)感染艾滋病患者病毒载量的作用及与常见机会感染发生的关系。方法选取艾滋病患者110例,采用流式细胞仪检测患者CD_4~+T细胞计数,采用全自动病毒载量仪检测患者HTV-1病毒载量。结果 110例患者中,HIV-1病毒载量(Log_(10))为1.43~6.51,平均为(4.41±1.02);CD_4~+T淋巴细胞<200个/μl者53例,≥200个/μl者57例。CD_4~+/T淋巴细胞<200个/μl患者HIV-1病毒载量明显高于CD_4~+T淋巴细胞≥200个/μl患者(P<0.05)。Spearman相关分析显示HIV-1病毒载量与CD_4~+T淋巴细胞水平呈负相关(r_s=-0.324,P<0.05)。病毒载量(Log_(10))<4.41组和≥4.41组口腔假丝酵母菌感染、细菌性肺炎、肺结核以及总机会感染发生比例差异无显著性(P>0.05)。CD_4~+T细胞<200个/μl AIDS患者机会感染发生率为89.47%,明显高于≥200个/μl患者。结论 HIV-1感染AIDS患者病毒载量与机会性感染无明显关系,但与患者CD_4~+T淋巴细胞数有关,而CD_4~+T淋巴细胞数与机会性感染有明显关系。
Objective To investigate the role of viral load in HIV-1-infected AIDS patients and its relationship with common opportunistic infections. Methods A total of 110 AIDS patients were selected. The CD4 + T cell count was measured by flow cytometry. The viral load of HTV-1 was detected by automated viral vector analyzer. Results Among 110 patients, the HIV-1 viral load (Log_ (10)) was 1.43 ~ 6.51 with an average of (4.41 ± 1.02) and 53 patients with CD_4 ~ + T lymphocytes <200 cells / μ in 57 cases. The HIV-1 viral load of CD_4 ~ + / T lymphocytes <200 cells / μl was significantly higher than that of CD_4 ~ + T lymphocytes≥200 cells / μl (P <0.05). Spearman correlation analysis showed that HIV-1 viral load was negatively correlated with CD_4 ~ + T lymphocyte level (r_s = -0.324, P <0.05). There was no significant difference in the incidence of bacterial pneumonia, tuberculosis and total opportunistic infections between the viral load (Log_ (10)) <4.41 group and the ≥4.41 group of Candida albicans infection (P> 0.05). The incidence of opportunistic infections in patients with CD_4 ~ + T cells <200 cells / μl AIDS was 89.47%, significantly higher than ≥200 cells / μl. Conclusion The viral load of HIV-1-infected AIDS patients is not related to opportunistic infections, but is related to the number of CD_4 ~ + T lymphocytes in patients infected with HIV-1. The number of CD_4 ~ + T lymphocytes is significantly related to opportunistic infections.