即使在疫苗覆盖率高的发达国家,百日咳仍然是一个全球公共卫生的难题。百日咳发病率的上升伴随着流行病学的改变,特别是青少年和成人的报告病例显著增多。事实上,被报告的病例只是冰山一角。因此,许多国家已采取青少年加强免疫的策略。现从全球百日咳的流行现状入手,详细分析百日咳再现的玄机,并介绍各国免疫策略的演变,从而为我国免疫决策提供依据。 Pertussis remains a global public health problem even in developed countries with high vaccine coverage. The increase in the incidence of whooping cough is accompanied by epidemiological changes, especially in adolescents and adults. In fact, the reported cases are just the tip of the iceberg. As a result, many countries have adopted strategies for adolescent immunization. Starting from the prevalence of pertussis in the world, this article analyzes the mystery of whooping cough reproduction in detail and introduces the evolvement of immunization strategies in different countries so as to provide evidence for our country’s immune policy-making.