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辅助Ｔ细胞（Ｔｈ）亚群功能失衡是系统性红斑狼疮（ＳＬＥ）发病机制中的重要环节。多数报道认为ＳＬＥ存在Ｔｈ亚群功能失衡（Ｔｈ２功能亢进和Ｔｈ１功能不足，从而出现Ｂ细胞过度活化，产生多种自身抗体，导致病理损伤。也有倾向于ＴＨ１占优势的报道。在其发病机制中，可能既有ＴＨ１类，又有ＴＨ２类细胞因子的参与；在疾病的不同阶段，失衡的种类也可能不同。探讨ＳＬＥ中影响Ｔｈ分化的因素，研究使Ｔｈ亚群向反方向转换，对控制ＳＬＥ的免疫失衡及其进一步的防治，有重要意义。
The imbalance of helper T cell (Th) subsets is an important link in the pathogenesis of systemic lupus erythematosus (SLE). Most reports suggest that there is a Th subset imbalance in Th1 function (Th2 hyperfunction and Th1 insufficiency, resulting in over-activation of B cells, resulting in multiple autoantibodies, leading to pathological lesions.) There are also reports of predominance of TH1 predominance , There may be both TH1 and TH2 cytokines involved, and at different stages of the disease, the types of imbalances may also be different.To explore the factors influencing Th differentiation in SLE, to reverse the Th subpopulation in the reverse direction, to control SLE immune imbalance and its further prevention and treatment, is of great significance.